Rahima A. Bhanji

Summary Background Recent advances in evaluation of body composition show body mass index to be inadequate in differentiating between body compartments in cirrhosis. Given the limitations of body mass index, body composition evaluation using computed tomography has been increasingly used as a non‐invasive clinical tool with prognostic value. Another factor influencing prognosis includes sex‐specific differences in body composition that are seen in cirrhosis.

Summary Background Sarcopenia is associated with both increased wait‐list mortality and mortality following liver transplantation. Aims To determine the course of sarcopenia from transplant evaluation until 1 year post‐transplant, and its implications on hospitalisation and mortality following liver transplantation.

1 INTRODUCTION Autoimmune hepatitis (AIH) is a rare and complex inflammatory liver disease characterised by interface hepatitis, high serum immunoglobulin G level, and autoantibodies.1, 2 Foreign antigens that resemble self‐antigens (molecular mimicry) probably activate naïve CD4+ helper T cells that differentiate and proliferate along cytokine pathways into liver‐infiltrating CD8+ cytotoxic T lymphocytes, antibody‐producing plasma cells, and Th17 lymphocytes.3, 4 Homologous epitopes distant...