Raja S. Mahidhara

Comparing the impact of targeting limited driving pressure to low tidal volume ventilation on mortality in mechanically ventilated adults with COVID-19 ARDS: an exploratory target trial emulation Statistics from Altmetric.com Request Permissions If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Airway wall remodeling contributes significantly to airway hyperresponsiveness that characterizes asthma (1). The increase in airway smooth muscle volume is believed to be important in airway remodeling, and can also perpetuate airway inflammation in asthma (1). Plasma and inflammatory cell–derived mediators are also known to induce airway smooth muscle proliferation (1, 2), resulting in further increase in airway smooth muscle cell volume.