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Rajagopalan Saranathan on Muck Rack

Rajagopalan Saranathan

As seen in: American Society for Microbiology (ASM)
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Articles

Characterization of Large Deletion Mutants of Mycobacterium tuberculosis Selected for Isoniazid Resistance

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By Catherine Vilcheze, Albert Einstein College, Brian Weinrick, Rajagopalan Saranathan
| American Society for Microbiology (ASM)
Mechanisms of Resistance Catherine Vilchèze, Rajagopalan Saranathan, Brian Weinrick, William R. Jacobs Jr. DOI: 10.1128/AAC.00792-20 ABSTRACT Large genomic deletions (LGDs) (6 to 63 kbp) were observed in isoniazid-resistant Mycobacterium tuberculosis mutants derived from four M. tuberculosis strains. These LGDs had no growth defect in vitro but could be defective in intracellular growth and showed various sensitivities toward oxidative stress despite lacking katG.
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