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Rajbharan Yadav

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Articles

Meropenem-Tobramycin Combination Regimens Combat Carbapenem-Resistant Pseudomonas aeruginosa in the Hollow-Fiber Infection Model Simulating Augmented Renal Clearance in Critically Ill Patients

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By Rajbharan Yadav, Phillip J. Bergen, Kate Rogers, Steven C Wallis
| asm.org
Pharmacology Rajbharan Yadav, Phillip J. Bergen, Kate E. Rogers, Carl M. J. Kirkpatrick, Steven C. Wallis, Yuling Huang, Jürgen B. Bulitta, David L. Paterson, Jeffrey Lipman, Roger L. Nation, Jason A. Roberts, Cornelia B. Landersdorfer DOI: 10.1128/AAC.01679-19 ABSTRACT Augmented renal clearance (ARC) is common in critically ill patients and is associated with subtherapeutic concentrations of renally eliminated antibiotics.
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Meropenem Combined with Ciprofloxacin Combats Hypermutable Pseudomonas aeruginosa from Respiratory Infections of Cystic Fibrosis Patients

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By Vanessa Rees, Rajbharan Yadav, Kate Rogers, Jürgen B. Bulitta
| asm.org
Pharmacology Meropenem Combined with Ciprofloxacin Combats Hypermutable Pseudomonas aeruginosa from Respiratory Infections of Cystic Fibrosis Patients Vanessa E. Rees, Rajbharan Yadav, Kate E. Rogers, Jürgen B. Bulitta, Veronika Wirth, Antonio Oliver, John D. Boyce, Anton Y. Peleg, Roger L. Nation, Cornelia B. Landersdorfer
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Evaluation of Pharmacokinetic/Pharmacodynamic Model-Based Optimized Combination Regimens against Multidrug-Resistant Pseudomonas aeruginosa in a Murine Thigh Infection Model by Using Humanized Dosing Schemes

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By Roger L. Nationa, Rajbharan Yadav, aDrug Delivery, Jürgen B. Bulitta
| American Society for Microbiology (ASM)
We previously optimized imipenem and tobramycin combination regimens against a double-resistant clinical Pseudomonas aeruginosa isolate by using in vitro infection models, mechanism-based pharmacokinetic/pharmacodynamic modeling (MBM), and Monte Carlo simulations. The current study aimed to evaluate these regimens in a neutropenic murine thigh infection model and to characterize the time course of bacterial killing and regrowth via MBM.
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