Rajul S Bains on Muck Rack

Rajul S Bains

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Articles

Vascularized tumor-on-a-chip to investigate immunosuppression of CAR-T cells

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By Rajul S Bains, Tara Raju, Layla C Semaan, Anton Block
| Royal Society of Chemistry Verified
Vascularized tumor-on-a-chip to investigate immunosuppression of CAR-T cells Chimeric Antigen Receptor (CAR)-T cell immunotherapy, effective in blood cancers, shows limited success in solid tumors, such as prostate, pancreatic, and brain cancers due, in part, to an immunosuppressive tumor microenvironment (TME). Immunosuppression affects various cell types, including tumor cells, macrophages, and endothelial cells.
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