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Ralf Bartenschlager on Muck Rack

Ralf Bartenschlager

As seen in: Color Research & Application, Nature, Wiley Online Library, MDPI, ZDF
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Articles

A coronavirus assembly inhibitor that targets the viral membrane protein - Nature

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By Manon Laporte, Dirk Jochmans, Lowiese Desmarets, Oliver Debski-Antoniak, Giulia Mizzon, Rana Abdelnabi, Pieter Leyssen, Winston Chiu, Norimichi Nomura, Umeharu Ohto, Yannick Stahl, Steven De Jonghe, Annelies Stevaert, Aneta Zegar, Katarzyna Owczarek, Niels Cremers, Jasper Rymenants, Krzysztof Pyrc, Jean Dubuisson, Berend-Jan Bosch, Etienne Decroly, Birgit Weynand, Eric J. Snijder, Sandrine Belouzard, Toshiyuki Shimizu, Ralf Bartenschlager, Daniel L. Hurdiss, Brenda W. Bontes, Frank Van Kuppeveld, Cecilia Eydoux
| Nature Verified
Abstract The coronavirus membrane protein (M) is the main organizer of coronavirus assembly1,2,3. Here, we report on an M-targeting molecule, CIM-834, that blocks the assembly of SARS-CoV-2. CIM-834 was obtained through high-throughput phenotypic antiviral screening followed by medicinal-chemistry efforts and target elucidation. CIM-834 inhibits the replication of SARS-CoV-2 (including a broad panel of variants) and SARS-CoV.
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Phosphatidylserine-exposing extracellular vesicles in body fluids are an innate defence against apoptotic mimicry viral pathogens - Nature Microbiology

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By Rüdiger Groß, Pascal von Maltitz, Laura Schneider, Markus Hoffmann, Dhanu Gupta, Stefan Pöhlmann, Christine Goffinet, Ralf Bartenschlager, Samir EL Andaloussi, Eva Herker, Frank Kirchhoff, Jan Münch, Hanna Reßin, Dan Albers
| Nature Verified
Abstract Some viruses are rarely transmitted orally or sexually despite their presence in saliva, breast milk, or semen. We previously identified that extracellular vesicles (EVs) in semen and saliva inhibit Zika virus infection. However, the antiviral spectrum and underlying mechanism remained unclear. Here we applied lipidomics and flow cytometry to show that these EVs expose phosphatidylserine (PS).
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SARS-CoV-2 nsp3 and nsp4 are minimal constituents of a pore spanning replication organelle - Nature Communications

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By Liv Zimmermann, Moritz Wachsmuth-Melm, Vibhu Prasad, Zach Hensel, Ralf Bartenschlager, Jana Makroczyova
| Nature Verified
Abstract Coronavirus replication is associated with the remodeling of cellular membranes, resulting in the formation of double-membrane vesicles (DMVs). A DMV-spanning pore was identified as a putative portal for viral RNA. However, the exact components and the structure of the SARS-CoV-2 DMV pore remain to be determined. Here, we investigate the structure of the DMV pore by in situ cryo-electron tomography combined with subtomogram averaging.
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