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Articles by Ralf Dechend
Endothelin antagonists and the quest for a new therapeutic option in resistant hypertension
Hypertension remains the leading risk factor for cardiovascular diseases.With its prevalence rising worldwide, we also see an increase in the number of patients with resistant hypertension—a condition where blood pressure remains above goal despite the use of three different classes of antihypertensive drugs, including a diuretic.Resistant hypertension is often part of multimorbidity including chronic kidney disease, obesity, diabetes, and ischaemic heart disease.
Risk prediction of maternal cardiovascular disease one year after hypertensive pregnancy complications or gestational diabetes mellitus
1. Lozano, R, Naghavi, M, Foreman, K, et al. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: A systematic analysis for the Global Burden of Disease Study 2010. Lancet 2012; 380: 2095–2128. Google Scholar | Crossref | Medline | ISI 2. Staff, AC, Redman, CW, Williams, D, et al. Pregnancy and long-term maternal cardiovascular health: Progress through harmonization of research cohorts and biobanks. Hypertension 2016; 67: 251–260.
CD74-Downregulation of Placental Macrophage-Trophoblastic Interactions in Preeclampsia
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Methods and Results: We performed whole-genome expression analysis of placental tissue. CD74 was one of the most downregulated genes in placentas from preeclamptic women. By reverse transcriptase-polymerase chain reaction, we confirmed this finding in early-onset (<34 gestational week, n=26) and late-onset (≥34 gestational week, n=24) samples from preeclamptic women, compared with healthy pregnant controls (n=28). CD74 protein levels were analyzed by Western blot and flow cytometry.
By Herbert Schulz, Friedrich C. Luft, Dominik Müller, Lukasz Przybyl, Nadine Haase, Michaela Golic, Julianna Rugor, Maria Emilia Solano, Petra Clara Arck, Martin Gauster, Berthold Huppertz, Christoph Emontzpohl, Christian Stoppe, Jürgen Bernhagen, Lin Leng, Richard Bucala, Arnd Heuser, M. Susanne Weedon-Fekjær, Guro M. Johnsen, Dirk Peetz, Ralf Dechend
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circres.ahajournals.org
Angiotensin II-induced sudden arrhythmic death and electrical remodeling
electrical remodeling involves acquired changes in cardiac structure or function that promote the occurrence of atrial or ventricular cardiac arrhythmias (22). On the molecular level, electrical remodeling involves changes in function and expression of membrane ion channels, gap-junction proteins, Ca2+-cycling proteins, and extracellular matrix composition. All these factors predispose to arrhythmogenic mechanisms such as early and delayed afterdepolarizations and reentry (13).
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