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Ramez Barbara on Muck Rack

Ramez Barbara

As seen in: Nature
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Articles

Aged differentiated cells reverse into native stemness-like state by niche cytokines to sustain lifelong homeostasis and tissue repair

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By Swarnabh Bhattacharya, Ofir Shorer, Aya Amitai-Lange, Anna L. Altshuler, Keren Yizhak, Yuval Shaked, Michael Mimouni, Beatrice Tiosano, Ramez Barbara, Ruby Shalom-Feuerstein, Shalini Dimri-Wagh, Gharam Yassen, Shira Hadad-Porat
| Nature Verified
Abstract Recent studies report that epithelial differentiated cells can undergo a reverse process called dedifferentiation in response to stem cell loss. However, the extent of this reversion and the plasticity of young versus aged-differentiated cells remain unclear. Here we show that dedifferentiated corneal epithelial cells acquire a transcriptomic state closely resembling native stem cells, sustain tissue homeostasis across lifespan and efficiently repair repeated tissue injury.
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Dupilumab-associated ocular surface disease: presentation, management and long-term sequelae

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By Michael R. Ardern-Jones, Parwez Hossain, Ramez Barbara, Magdalena Z. Popiela
| Nature Verified
Abstract Objectives To determine the presenting features of ocular surface disease in patients with atopic dermatitis (AD) treated with dupilumab at a tertiary, university hospital. To establish the need for treatment of dupilumab-associated ocular surface disease and report any long-term effects on the ocular surface. Methods A retrospective analysis of consecutive patients treated with dupilumab for AD between January 2017 and August 2019 was undertaken.
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The future of refractive surgery: presbyopia treatment, can we dispense with our glasses?

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By Parwez Hossain, Hospitals Trust Southampton, Ramez Barbara
| Nature Verified
Refractive error remains the leading cause for visual impairment. With an aging world population, presbyopia is the leading refractive deficit. In many parts of the developed world, the average person can spend half of their lives in presbyopia [1]. With increasing digital demands, there is an increasing dependence on accommodation and presbyopic symptoms can appear as early as the 30s age group [2].
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