Rampazzo Morelli on Muck Rack

Rampazzo Morelli

As seen in: Diabetes Spectrum
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Articles

Insulin production is sustained during DNA damage-mediated senescence in adult human beta cells - Diabetologia

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By Rampazzo Morelli, C. E. Bruce, Rady Faculty
| link.springer.com
Abstract Residual pancreatic beta cells in type 1 diabetes show reduced insulin production but the mechanisms remain unclear. Beta cells undergo stress responses during type 1 diabetes, including endoplasmic reticulum (ER) stress and DNA damage-associated senescence, which may affect insulin production. ER stress reduces insulin production but whether senescence disrupts insulin production in human beta cells has not been investigated.
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Autoreactive T Cells and Cytokine Stress Drive β-Cell Senescence Entry and Accumulation in Type 1 Diabetes

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By Roozbeh Akbari, Rampazzo Morelli
| Diabetes Spectrum
This article contains supplementary material online at https://doi.org/10.2337/figshare.29129000. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. More information is available at https://www.diabetesjournals.org/journals/pages/license.
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