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Articles by Ramya Narasimhan
Generalist and human-restricted Salmonella evolved divergent human intestinal epithelial cell tropism
Abstract Generalist and human-restricted Salmonella enterica serovars cause diseases ranging from gastroenteritis to typhoid fever. Using live-imaging with controlled-polarity human intestinal epithelial cell (IEC) organoids, we identify epithelial cell sensing as a pre-invasion stage of infection. The generalist serovar Typhimurium migrates toward apical but away from basolateral IEC surfaces, whereas the human-restricted serovar Typhi exhibits the opposite behavior.
Article: The transformative role of mentorship for women in tech
Leadership Development Mentorship plays a crucial role in bridging the gender gap in tech, empowering women to overcome challenges and excel in their careers. The technology industry has witnessed profound changes, yet one persistent challenge endures—the underrepresentation of women.
Salmonella enterica serovar Typhi uses two type 3 secretion systems to replicate in human macrophages and to colonize humanized mice
New Results doi: https://doi.org/10.1101/2023.06.06.543980 Abstract Salmonella enterica serovar Typhi (S. Typhi) is a human-restricted pathogen that replicates in macrophages. In this study, we investigated the roles of the S. Typhi Type 3 secretion systems (T3SSs) encoded on Salmonella Pathogenicity Islands (SPI) -1 (T3SS-1) and -2 (T3SS-2) during human macrophage infection. We found that mutants of S.
Teaching NeuroImage: Imaging and Pathologic Findings in SARS-CoV-2-Related Acute Demyelinating Encephalomyelitis
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Teaching NeuroImage: Imaging and Pathologic Findings in SARS-CoV-2-Related Acute Demyelinating Encephalomyelitis
REQUIREMENTS If you are uploading a letter concerning an article: You must have updated your disclosures within six months: http://submit.neurology.org Your co-authors must send a completed Publishing Agreement Form to Neurology Staff (not necessary for the lead/corresponding author as the form below will suffice) before you upload your comment.
A Higher Foci Density of Interstitial Fibrosis and Tubular Atrophy Predicts Progressive Chronic Kidney Disease after a Radical Nephrectomy for Tumor
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Kidney Microstructural Features at the Time of Donation Predict Long-term Risk of Chronic Kidney Disease in Living Kidney Donors
Abstract Objective To determine whether microstructural features on a kidney biopsy specimen obtained during kidney transplant surgery predict long-term risk of chronic kidney disease in the donor. Patients and Methods We studied kidney donors from May 1, 1999, through December 31, 2018, with a follow-up survey for the results of recent blood pressure and kidney function tests (estimated glomerular filtration rate [eGFR] and proteinuria).
Glomerular Volume and Glomerulosclerosis at Different Depths within the Human Kidney
This article requires a subscription to view the full text. If you have a subscription you may use the login form below to view the article. Access to this article can also be purchased. Significance Statement Research investigating glomerular morphology in different cortical regions has been limited to animal models and a small number of human autopsy kidneys.
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