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Raphael Bar-Or on Muck Rack

Raphael Bar-Or

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Articles

Beyond cartilage degeneration: osteoarthritis as a systems failure of inflammation regulation

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By Jason Williams, Melissa A. Hausburg, Greg Thomas, David Bar-Or, Raphael Bar-Or
| Frontiers
Abstract Osteoarthritis (OA) is traditionally framed as a degenerative cartilage disease caused by age-related mechanical wear. However, this paradigm does not adequately account for the synovitis, metabolic disturbance, and pain that commonly precede overt structural loss. In this Hypothesis and Theory article, we propose a testable systems model in which OA reflects a failure of interdependent synovial regulatory networks rather than a purely structural endpoint.
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