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Raquel Alsina on Muck Rack

Raquel Alsina

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Articles

Amyloid and aging reshape glial waste management in APP/PS1 mice

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By Clara Romera, Marta Riba, Miren Ettcheto, Antoni Camins, Jordi Vilaplana, Carme Pelegri, Jaume del Valle, Marina Sartorio, Raquel Alsina
| Nature Verified
Abstract Several IgM-reactive structures have recently been proposed as components of glial and meningeal waste-handling pathways in mice: Periodic Acid-Schiff (PAS)-positive polyglucosan granules, extraparenchymal (EP) IgM+ granules, and a population of IgM+ astrocytes. Here, we analyzed brain specimens to describe how these three structures change with age and amyloid pathology in APPswe/PS1dE9 female mice and C57BL/6 littermate controls at 3, 6, 12, and 22 months of age.
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