Rasha Al Mismar

Editors' Choice CANCER Wei Wong https://orcid.org/0009-0008-7154-4108 Authors Info & Affiliations Abstract Repeat RNAs reprogram tumor cells and cancer-associated fibroblasts in pancreatic cancer. SIGN UP FOR THE AWARD-WINNING SCIENCEADVISER NEWSLETTER The latest news, commentary, and research, free to your inbox daily Cancers frequently show increased expression of repeat RNAs, which arise from repetitive elements in the genome. You et al.

Editor’s summary Proximity labeling using the biotin ligase TurboID enables the identification of proteins that interact directly or indirectly inside cells. To extend the reach of this method to the extracellular side of the plasma membrane, Al Mismar et al. developed a form of TurboID optimized for use on the cell surface.

Abstract Plasma membrane proteins are critical mediators of cell-cell and cell-environment interactions, pivotal in intracellular signal transmission vital for cellular functionality. Proximity-dependent biotinylation approaches such as BioID combined with mass spectrometry have begun illuminating the landscape of proximal protein interactions within intracellular compartments. However, their deployment in studies of the extracellular environment remains scarce.