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Rasha Barakat on Muck Rack

Rasha Barakat

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Articles

Human single cell RNA-sequencing reveals a targetable CD8+ exhausted T cell population that maintains mouse low-grade glioma growth - Nature Communications

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By Jit Chatterjee, Rui Mu, Jonathan Kipnis, Rasha Barakat
| Nature Verified
Abstract In solid cancers, T cells typically function as cytotoxic effectors to limit tumor growth, prompting therapies that capitalize upon this antineoplastic property (immune checkpoint inhibition; ICI). Unfortunately, ICI treatments have been largely ineffective for high-grade brain tumors (gliomas; HGGs).
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