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Ratnal Belapurkar on Muck Rack

Ratnal Belapurkar

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A transient increase of HIF-1α during the G1 phase (G1-HIF) ensures cell survival under nutritional stress - Cell Death & Disease

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By Sven Zukunft, Ingrid Fleming, Michael Kracht, Ratnal Belapurkar
| Nature Verified
Abstract The family of hypoxia-inducible transcription factors (HIF) is activated to adapt cells to low oxygen conditions, but is also known to regulate some biological processes under normoxic conditions. Here we show that HIF-1α protein levels transiently increase during the G1 phase of the cell cycle (designated as G1-HIF) in an AMP-activated protein kinase (AMPK)-dependent manner.
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