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Razali Mirad on Muck Rack

Razali Mirad

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Integrated risk characterization of estragole, aristolochic acids, and pyrrolizidine alkaloids in natural products using margin of exposure and RISK21

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By Mohd Yusmaidie Aziz, Manraj Singh Cheema, Amin Ismail, Ahmad Rohi Ghazali, Rozaini Abdullah, Mohd Firdaus Razali, Razali Mirad
| Nature Verified
Abstract Natural products (NPs) including herbal teas are widely consumed in Malaysia but lack stringent regulation. Naturally occurring phytochemicals including estragole (genotoxic), aristolochic acids (AAs; Group 1 carcinogen) and certain pyrrolizidine alkaloids (PAs; Group 2B carcinogen) pose severe hepatotoxic and nephrotoxic risk. An integrated risk assessment using the Margin of Exposure (MOE) and the RISK21 framework was applied to 90 NPs (30 per compound).
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