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Hypoxia activates SREBP2 through Golgi disassembly in bone marrow‐derived monocytes for enhanced tumor growth

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By Ryuichi Nakahara, RCAST The, Sho Aki, Maki Sugaya
| embopress.org
Introduction Bone marrow-derived cells (BMDCs) have been shown to infiltrate into and differentiate within hypoxic tumor regions, thereby stimulating angiogenesis, matrix organization, and pro-tumorigenic immunity (Coussens et al, 2000; Ferrara & Kerbel, 2005; Shibuya & Claesson-Welsh, 2006; Shojaei et al, 2007; Du et al, 2008; Ostrand-Rosenberg, 2008).
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