Réactivité de l’ARN

Loading metrics Open Access Peer-reviewed Research Article ? This is an uncorrected proof. Citation: Gaucherand L, Marie H, Cremaschi J, Pfeffer S (2025) Bat Dicer antiviral role and subcellular localization differ upon alphavirus infection in two distinct species. PLoS Pathog 21(12): e1013815. https://doi.org/10.1371/journal.ppat.1013815 Editor: Ronald P.

The number of transfer RNA (tRNA) genes varies extensively across different species, and in bacteria is neither evenly nor randomly distributed among genomes. Even closely related species, which may have minor differences in genome size can exhibit significant variations in their tRNA gene sets [1, 2]. This variability in the tRNAome is linked to evolutionary adaptations in codon usage and to some extent to the number of tRNA-derived fragments with additional regulatory roles [3].

A diversity of regulatory RNA classes in a wide phylogeny have been described that control RNA through sequence-specific base pairing with target RNAs. Several classes of regulatory RNA, including eukaryotic microRNA (miRNA) and PIWI-interacting RNA, as well as the single guide RNA central to the CRISPR–Cas9 system, have very well-defined length, structure, and sequence requirements that promote interactions with protein partners and present specific nucleotides for target pairing [1, 2].