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Rebeca Uceda Castro on Muck Rack

Rebeca Uceda Castro

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Articles

PUM3 is an essential suppressor of replication stress in homologous recombination deficient breast cancer

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By Valeria Amodeo, Daniel Weekes, Nicolae Balan, Nadja D’Uonno, Asha Konde, Elodie Noël, Jennifer Trendell, Callum Walker, Anjan Venkatesh, Colm J. Ryan, Sarah Moser, Jos Jonkers, Laurence H. Pearl, Antony Oliver, Dragomir B. Krastev, Syed Imran Haider, Anita Grigoriadis, Stephen Pettitt, Christopher Lord Verified, Andrew Tutt, Rebeca Uceda Castro, Luisa Robbez-Masson, Maya Shlomi
| Nature Verified
Abstract Most Triple Negative Breast Cancers (TNBCs) are p53 mutant high-grade invasive ductal carcinomas with a basal-like transcriptional programme. A large proportion of TNBCs also have mutation signatures indicating defective homologous recombination (HR) DNA repair. While HR deficiency is mutagenic and oncogenic, it can also compromise cell fitness.
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