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Rebecca Bruning-Barry on Muck Rack

Rebecca Bruning-Barry

As seen in: ASM Journals, medRxiv
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Articles

Cardiodynamic evaluation of sorfequiline (TBAJ-876): results from a first-in-human study

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By Borje Darpo, Jerry R. Nedelman, Rebecca Bruning-Barry, Dean A. Hickman
| ASM Journals
INTRODUCTION Bedaquiline, a diarylquinoline approved for multidrug-resistant tuberculosis (1–4), prolongs the corrected QT (QTc) interval through its N-desmethyl metabolite (4–8). Because several tuberculosis drugs prolong QTc, the potential for additive effects remains a safety concern (6, 7, 9–14). Sorfequiline (TBAJ-876) is a next-generation diarylquinoline discovered by the TB Alliance to maintain potent antimycobacterial activity while minimizing risk of QTc prolongation (15).
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Hepatic safety of pretomanid- and pyrazinamide-containing regimens in TB Alliance clinical trials

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By Jerry R. Nedelman, Mengchun Li, Morounfolu Olugbosi, Rebecca Bruning-Barry
| medRxiv
JA and RB-B: Consultants for TB Alliance paid through RTI International. MB, JN, MO, ES: Employees of TB Alliance. ML: Former employee of TB Alliance. MB: Stock in J&J. SG: Grants or contracts from TB Alliance, EDCTP. ML: Stock in J&J, Merck. JN: Stock in Novartis, Sandoz. DS: Grant from EDCTP; member of Medical Monitoring Team for SimpliciTB.
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