Rebecca Chiu

Abstract Genomic studies at single-cell resolution have identified several cell types associated with clinical and pathological traits in Alzheimer’s disease1,2,3,4,5,6,7,8,9, but have not examined associations that are shared across populations.

Abstract Human microglial heterogeneity is only beginning to be appreciated at the molecular level. Here, we present a large, single-cell atlas of expression signatures from 441,088 live microglia broadly sampled across a diverse set of brain regions and neurodegenerative and neuroinflammatory diseases obtained from 161 donors sampled at autopsy or during a neurosurgical procedure.

By now, unless you’ve been living under a rock, you know that Sarah Palin is rumored to be the next U.S. ambassador to Canada. While she may be a self-professed hockey mom, most people north of the border, from national politicians to the average Twitterer, didn’t respond to the suggestion in equal adoration. So Canada, let’s prepare for the possibility that the mama grizzly could be our connection to the U.S. of A.