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Rebekah de Nys on Muck Rack

Rebekah de Nys

As seen in: Nature
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Harnessing colorectal tumour enriched glutamate to improve E. coli Nissle tumour specificity

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By Sara Foschini, Kate Barratt, Sadia Hasan, Julia Leeflang, Paul J Trim, Marten F. Snel, Georgette Radford, Tharindie N. Silva, Laura Vrbanac, Josephine Wright, Susan Woods, Rebekah de Nys, Andrew Menelaou
| Nature Verified
Abstract Engineered tumour-homing bacteria are a promising targeted treatment option for colorectal cancer (CRC). However, little is known about why they home to tumours. To investigate potential metabolic drivers of E. coli Nissle (EcN) tumour-homing, we performed targeted amino acid metabolomics using orthotopic mouse models of CRC. We identified enriched glutamate and asparagine in the tumour when compared to healthy colon tissue.
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