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Reiki Nishimura on Muck Rack

Reiki Nishimura

As seen in: Journal of Clinical Pathology
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Articles

The importance of tissue handling of surgically removed breast cancer for an accurate assessment of the Ki-67 index

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By Nobuyuki Arima, Reiki Nishimura, Tomofumi Osako, Yasuyuki Nishiyama, Mamiko Fujisue
| Journal of Clinical Pathology Verified
Conclusions Tissue handling of surgical specimen is critical for assessing the Ki-67 compared with ER and HER2. We should pay more attention to tissue fixation status for the standard assessment of the Ki-67 index. Results The Ki-67 was significantly higher when 10% neutral buffered formalin was used (p=0.0276). Insufficient fixation caused a drastic reduction in the Ki-67 index (p=0.0177), but not significant in oestrogen receptor (ER) and human epidermal growth factor receptor 2 (HER2).
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