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Reiko Tsuchiya on Muck Rack

Reiko Tsuchiya

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Articles

Glomerular routing of tumor-derived extracellular vesicles substantiates urinary biopsy

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By Karolin Voßgröne, Sabrina Y. Camp, Haiyan Chu, Shota Kawaguchi, Taiga Ajiri, Koki Kunitake, Yoshikazu Tanaka, Takeshi Yokoyama, Kiichi Sato, Yusuke Sato, Zetao Zhu, Kunanon Chattrairat, Yasuko Kobayashi, Kimiko Inoue, Keisuke Imaeda, Kosei Ueno, Sou Ryuzaki, Akira Kato, Rina Mitsuya, Reiko Tsuchiya
| Science Magazine Verified
Abstract Urinary small extracellular vesicles (sEVs), which can reflect systemic conditions, hold great promise for noninvasive cancer diagnostics, yet the mechanism by which tumor-derived sEVs reach urine remains unclear. Here, we demonstrate that the glomerulus actively transcytoses circulating tumor-derived sEVs into urine.
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