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Rekin’s Janky

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Articles

The complexome contextualizes proteomics data to fingerprint biological states and highlight perturbed functional modules in disease

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By Mainak Guharoy, Isabelle Adant, Matthew Bird, Alexander Botzki, James Collier, Jonas Dehairs, Simon Devos, Geert Goeminne, Francis Impens, Andrea Janez Pedrayes, Pedro Magalhães, Teresa Maia, Wouter Meersseman, Daisy Rymen, Johannes V. Swinnen, Delphi Van Haver, Dries Verdegem, Peter Witters, David Cassiman, Bart Ghesquière, Stefaan Derveaux, Rekin’s Janky, Ruth Maes
| Nature Verified
Abstract Analyzing single omics and integrating multimodal omics datasets to capture functional dysregulation in disease remains challenging. Here, we propose a bioinformatics framework that leverages curated datasets of protein complexes (‘complexome’) as a foundation for proteomics data integration. Available for human and other model organisms, the complexome provides a global view of cellular function, enabling queries with proteomics datasets.
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