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Rena Theda Overbeck

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Articles

Stage‐Dependent Inhibitory Connectivity in Striatal‐Motor Circuit in Huntington's Disease

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By Imis Dogan, Kathrin Reetz, Yinghua Jing, Rena Theda Overbeck
| Wiley Online Library Verified
1 Introduction Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused by a cytosine-adenine-guanine (CAG) repeat expansion in the Huntingtin gene (HTT) [1]. Accumulated toxicity of the mutant HTT (mHTT) protein leads to cellular degeneration of neurons in the brain (especially in the striatum), thereby progressively impairing the motor, cognitive, and psychiatric abilities of patients leading to death [2].
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