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Renati Yimamu on Muck Rack

Renati Yimamu

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Articles

The CHMP4C-IGF2BP3 axis drives osimertinib resistance in lung cancer through ZBP1 mRNA degradation and subsequent necroptosis suppression

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By Xiaomeng Zhang, Zhichao Wu, Chengyu Jin, Jinshan Ma, Renati Yimamu, Yuzhen Zong, Yilizhati Nijiati
| Nature Verified
Abstract Osimertinib (OSI) resistance in lung cancer (LC) remains a major clinical challenge. This study elucidates the role of charged multivesicular body protein 4 C (CHMP4C) in this resistance and its underlying mechanism. OSI-resistant (OR) LC cell lines (PC9/OR, HCC827/OR) were established. CHMP4C was knocked down using short hairpin RNA. Cell viability, clonogenicity, and death were assessed by cell counting kit-8, colony formation, and Annexin V/propidium iodide assays.
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