Renaud Tissier

ABBREVIATIONS c (clinical) CI (confidence interval) CT (computed tomography) EMVI (extramural venous invasion) ICC (intraclass correlation coefficient) NA (not available) OR (odds ratio) p (pathological) RSM (retroperitoneal surgical margin) TD (tumor deposits) WMO (Medical Research Involving Human Subjects Act) Key Words Colonic neoplasms X-ray computed tomography Neoplasm staging Neoadjuvant therapy INTRODUCTION Colon cancer remains a significant global health concern and is one of the most...

DISCUSSION This study shows that accuracy for yT-staging on restaging MRI after CRT is greatly reduced in patients with a more favourable tumour response and increasing levels of fibrosis. Accuracy for ymrT-staging is significantly higher in patients who show predominant tumour at histology (pTRG4–5). In this subgroup, the overall ymrT/ypT stage concordance was 55% for nonexpert and 67% for expert readers, with overstaging rates of only ≤15%.

4. Discussion This study aimed to explore the ability of MR diffusion-based imaging parameters, extracted from MR-imaging acquired at baseline and after immunotherapy treatment (shortly prior to surgery), to predict or detect major pathological responses to neoadjuvant ICB early on in patients with resectable HNSCC. Several differences were seen at the baseline between the pathological response groups in our data.