Renchu Guan

Abstract Spatial omics face challenges in achieving high-parameter, multi-omics coprofiling. Serial-section profiling of complementary panels mitigates technical trade-offs but introduces the spatial diagonal integration problem. To address this, here we present SpatialEx and its extension SpatialEx+, computational frameworks leveraging histology as a universal anchor to integrate spatial molecular data across tissue sections.

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All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.