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Rendan Yang

As seen in: Nature, Science Magazine, Cell Reports
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Articles by Rendan Yang

Mitochondrial stress activates ELT-2–dependent lysosomal proteostasis to extend lifespan in C. elegans

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By Lele Zhang, Jordan Houri, Doan T Dinh, Rendan Yang, Yu Sun, Wenzheng Wang, Yuxuan Lei, Lin Chen, Xiaoxu Li, Raya B. Liu, Ang Zhou, Arwen W. Gao, Liangshan Mu, Johan Auwerx
| Science Magazine Verified
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Mild mitochondrial stress could extend lifespan across species, yet the underlying mechanism remains unclear.
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A lysosomal surveillance response to stress extends healthspan - Nature Cell Biology

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By Arwen W. Gao, Rendan Yang, Yu Sun, Xiaoxu Li, Wenzheng Wang, Tong-Jin Zhao, Qi Wang, Riekelt Houtkooper
| Nature Verified
Abstract Lysosomes are cytoplasmic organelles central for the degradation of macromolecules to maintain cellular homoeostasis and health. However, how lysosomal activity can be boosted to counteract ageing and ageing-related diseases remains elusive. Here we reveal that silencing specific vacuolar H+-ATPase subunits (for example, vha-6), which are essential for intestinal lumen acidification in Caenorhabditis elegans, extends lifespan by ~60%.
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NHR-80 senses the mitochondrial UPR to rewire citrate metabolism for lipid accumulation in Caenorhabditis elegans

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By Yunnan Agricultural, Yamei Li, Rendan Yang
| Cell Reports Verified
Highlights • Inactivation of the TCA cycle or dietary citrate elicits the UPRmt pathway • DVE-1 responds to citrate-induced UPRmt to regulate lipid metabolism • NHR-80 acts downstream of DVE-1 to transactivate lipogenesis under citrate stress Summary Mitochondria are known as the powerhouse of the cell. Dysfunction of mitochondria homeostasis induces the mitochondrial unfolded protein response (UPRmt), altering cellular metabolism. How cells sense the UPRmt to rewire metabolism is largely unknown.
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