Renée Brown Frandsen

1 Introduction Haemophilia, a congenital bleeding disorder caused by coagulation factor VIII (FVIII) or factor IX (FIX) deficiency (in haemophilia A [HA] and haemophilia B [HB], respectively), is commonly associated with musculoskeletal damage caused by repeated bleeding episodes in the joints and muscles [1]. The haemophilia burden of disease is associated with compromised joint health, joint pain, reduced physical activity and reduced health-related quality of life (HRQoL) [2, 3].