Renee Butler

Abstract Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a familial cardiac disease associated with ventricular arrhythmias and an increased risk of sudden cardiac death. Currently, there are no approved treatments that address the underlying genetic cause of this disease, representing a significant unmet need. Mutations in Plakophilin-2 (PKP2), encoding a desmosomal protein, account for approximately 40% of ARVC cases and result in reduced gene expression.

The United Kingdom officially withdrew from the European Union (EU) on Jan 31, 2020. They have until Dec 31, 2020 to complete all plans relating to the transition or exit. How does this impact the clinical trial landscape of research conducted within the United Kingdom? Well, it means there is an environment to navigate today and an environment to navigate after Dec 31, 2020.

Living with celiac disease is hard. Even when you do everything right, you still don’t feel quite right. It’s almost as if you have a cold that you can’t shake, where you feel a little weary, a little cloudy, a little faded. It’s been over a year since my diagnosis and I’ve never fully lost that feeling. At the same time, I’m developing more issues. After confirming I have celiac disease, I developed Reynauds.