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Rengang Luo on Muck Rack

Rengang Luo

As seen in: Nature, BioRxiv
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Articles

Misregulation of T-box transcription factors drives BNP–NPR1 signalling underlying chronic itch

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By Xiaolong Dai, Michael Kitching, Wenke Cheng, Rengang Luo, Lianlian Li, Weiwei Chen, Timo Buhl, Andrea Szegedi, Jörg Buddenkotte, Jiafu Wang, Jianghui Meng, Renkai Zhu, Chunxu Shan, Shouming Xu
| Nature Verified
Abstract Chronic itch poses a significant clinical burden, with activation of the brain natriuretic peptide (BNP) pathway as a hallmark, though its transcriptional control remains unclear. We identify T-box transcription factor 20 (TBX20) as upregulated in skin of atopic dermatitis patients, with increased expression in NPR1+ keratinocytes. ChIP peak calling, ChIP-qPCR and dual-luciferase assays show TBX20 activates the NPR1 promoter.
Open in Who Shared Issue with article?

Bacterial-tyramine-induced renal-gut countercurrent flow regulates gut immune response by promoting ROS accumulation and gut peristalsis in the fly Bactrocera dorsalis

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By Yanning Liu, Hongyu Zhang, Rengang Luo, Bruno Lamaitre
| BioRxiv
Abstract Insects increase gut peristalsis to purge ingested pathogens. They also rely on the Duox-ROS system to mount an efficient gut response. However, how these two host defense mechanisms are coordinated to clear pathogens remained unclear. We found that gut peristalsis is the major force for bacteria elimination, while Duox is necessary as a signaling molecule to activate gut peristalsis in a Tephritidae fruit fly Bactrocera dorsalis.
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