Renita Holmes on Muck Rack

Renita Holmes

As seen in: Nature
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Articles

Small extracellular vesicle signaling and mitochondrial transfer reprogram T helper cell function in human asthma

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By Kenneth P. Hough, Jennifer Trevor, Shaheer Ahmad, Yong Huei Wang, Balu K. Chacko, Kayla F. Goliwas, John G. Strenkowski, Yuelong Liu, Joanna Nowak, Eugene Becker Jr., Young-il Kim, Nathaniel B. Bone, Shia Vang, Sandeep Bodduluri, Veena Antony, Mohammad Athar, Jaroslaw W. Zmijewski, Jianhua Zhang, Steven R. Duncan, Victor J Thannickal, Susanne Gabrielsson, Victor Darley-Usmar, Jessy Deshane, Renita Holmes, Alexandra Pritchard, Jay Chin, Diptiman Chanda, Kasturi Mitra
| Nature
Abstract Small extracellular vesicles (sEVs) orchestrate cell-cell communication, but the role of sEV signaling via mitochondria in perpetuating asthmatic airway inflammation is unknown. Myeloid-derived regulatory cells (MDRCs) control CD4+ T cell responses in asthma. We demonstrate that airway MDRC-derived sEVs from asthmatics mediate T cell receptor engagement and transfer of mitochondria that induce antigen-specific activation and polarization of Th17 and Th2 cells.
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