Renmeng Liu on Muck Rack

Renmeng Liu

As seen in: Drug Metabolism and Disposition (ASPET)
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Articles

CYP7A1 Gene Induction via SHP-Dependent or Independent Mechanisms can Increase the Risk of Drug-Induced Liver Injury Independently or in Synergy with BSEP Inhibition

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By Congrong Niu, Xiaodong Xie, Renmeng Liu, Xiaomin Liang
| Drug Metabolism and Disposition (ASPET)
Abstract Drug-induced liver injury (DILI) is a frequent cause of clinical trial failures during drug development. While inhibiting bile salt export pump (BSEP) is a well-documented DILI mechanism, interference with genes related to bile acid (BA) metabolism and transport can further complicate DILI development.
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CYP7A1 gene induction via SHP-dependent or independent mechanisms can increase the risk of drug-induced liver injury independently or in synergy with BSEP inhibition

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By Xiaodong Xie, Renmeng Liu, Xiaomin Liang, Congrong Niu
| Drug Metabolism and Disposition (ASPET)
Abstract Drug-induced liver injury (DILI) is a frequent cause of clinical trial failures during drug development. While inhibiting BSEP is a well-documented DILI mechanism, interference with genes related to bile acid (BA) metabolism and transport can further complicate DILI development. Here, the effects of twenty-eight compounds on genes associated with BA metabolism and transport were evaluated, including those with discontinued development or use, boxed warnings, and clean labels for DILI.
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Assessing Pleiotropic Effects of a Mixed-mode Perpetrator Drug Rifampicin by Multiple Endogenous Biomarkers in Dogs

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By Renmeng Liu, Bin Ma, Bin Guo Ma, Bernard Murray, Marilyn M. Mok
| Drug Metabolism and Disposition (ASPET)
Abstract Rifampicin (RIF) is a mixed-mode perpetrator that produces pleiotropic effects on liver cytochrome P450 (CYP) enzymes and drug transporters. To assess the complex drug-drug interaction (DDI) liabilities of RIF in vivo, a known probe substrate midazolam (MDZ) along with multiple endogenous biomarkers were simultaneously monitored in beagle dogs before and after a 7-day treatment period by RIF at 20 mg/kg/day.
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