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Renqin Wang

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Articles

The Paracrine Effect of Hyaluronic Acid-Treated Endothelial Cells Promotes BMP-2-Mediated Osteogenesis

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By Jin Chen, Dan Hou, Xiaojie Tong, Renqin Wang
| MDPI
1. Introduction Bone morphogenetic protein-2 (BMP-2) is a commonly used osteogenic factor for bone tissue regeneration [,]. However, excessive doses of BMP-2 are associated with several major unintended side effects that can seriously damage patients’ health and musculoskeletal functions, such as ectopic bone formation, paralysis, osteosarcoma growth, and neurological disturbances [,,]. Osteogenesis, angiogenesis, and their coupling are highly crucial for bone regeneration [,,].
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