Renu Geetha Bai

Publication Date 9-1-2023 Journal Cancer and Metastasis Reviews DOI 10.1007/s10555-023-10099-x PubMedCentral® Posted Date 3-27-2023 PubMedCentral® Full Text Version Post-print Published Open-Access yes Keywords Humans, RNA Interference, RNA, Small Interfering, Neoplasms, Carcinogenesis, Drug Delivery Systems, Oral RNAi, RNAi therapeutics, Oral medicines, Cancer, Bioengineering Abstract Cancer is a major health concern worldwide and is still in a continuous surge of seeking for effective...

Bile acid linked β-glucan nanoparticle for liver specific oral delivery of biologics Oral delivery remains one of the most convenient routes for drug administration compared to intravenous, intramuscular, and via suppositories. However, due to the risk of degradation, and proteolysis of molecules in the acidic gastric medium, as well as difficulty of transporting of large molecules through the intestinal membrane, more than half of therapeutic molecules are prohibited for oral administration.