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Articles

Stratification of brain-derived extracellular vesicles of Alzheimer’s disease patients indicates a unique proteomic content and a higher seeding capacity of small extracellular vesicles | Translational Neurodegeneration

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By Lille Neuroscience, Réponse Inflammatoire, Spectrométrie de Masse
| link.springer.com
Abstract Alzheimer’s disease (AD) is the most prominent form of dementia worldwide. It is characterized by tau lesions that spread throughout the brain in a spatio-temporal manner. This has led to the prion-like propagation hypothesis implicating a transfer of pathological tau seeds from cell to cell. Human brain-derived extracellular vesicles (BD-EVs) isolated from the brain-derived fluid of AD patients contain seeds that contribute to this tau pathology spreading.
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Sex-dependent effects of maternal high-fat diet during lactation in the offspring of adult THY-Tau22 mice

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By Lille Neurosciences, CHU Lille, LabEx DISTALZ, Réponse Inflammatoire
| Oxford Academic Verified
The perinatal environment has been suggested to participate in the development of tauopathies and Alzheimer’s disease but the molecular and cellular mechanisms involved remain contradictory and under-investigated. Here, we evaluated the effects of a maternal high-fat diet (HFD) during lactation on the development of tauopathy in the THY-Tau22 mouse strain, a model of progressive tau pathology associated with cognitive decline.
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Cumulative learning enables convolutional neural network representations for small mass spectrometry data classification

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By Philippe Saudemont, Réponse Inflammatoire, Spectrométrie de Masse, Khawla Seddiki
| hal.science
Article Dans Une Revue Nature Communications Année : 2020 Cumulative learning enables convolutional neural network representations for small mass spectrometry data classification Domaines Intelligence artificielle [cs.AI] Apprentissage [cs.LG] Ingénierie biomédicale Fichier principal s41467-020-19354-z.pdf (689.97 Ko) Télécharger le fichier Origine : Publication financée par une institution hal-03132326 , version 1 (08-02-2024) Khawla Seddiki, Philippe Saudemont, Frédéric Precioso, Nina...
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