Rezayati Charan

Introduction Click to copy section linkSection link copied! Circulating tumor cells (CTCs) originate in primary tumors or metastases and are spread to new sites by the peripheral vascular system. It is desirable to capture CTCs with a liquid biopsy; (1) however, CTCs are extremely rare, (2) which makes it difficult to isolate them with high purity.

Introduction Click to copy section linkSection link copied! Circulating tumor cells (CTCs) originate in primary tumors or metastases and are spread to new sites by the peripheral vascular system. It is desirable to capture CTCs with a liquid biopsy; (1) however, CTCs are extremely rare, (2) which makes it difficult to isolate them with high purity.

Single-cell phenotyping based on biophysical properties is a promising tool to distinguish cell types and their response to a given condition, and charting such properties also enables optimization of cell separations. Isoacoustic focusing, where cells migrate to their points of zero acoustic contrast in an acoustic impedance gradient, added the effective acoustic impedance of cells to the directory of biophysical properties that can be utilized to categorize or separate cells.