Rhéure Alves-Lopes

1 INTRODUCTION Angiogenesis, the formation of new blood vessels from pre-existing vasculature, is a fundamental process in both physiological and pathological contexts. From embryonic development and wound healing to tumour growth and metastasis, the formation of new blood vessels plays a pivotal role (Saman et al., 2020).

Abstract The etiology of hypertension involves complex interactions between genetic, environmental and pathophysiological factors that influence many regulatory systems. Hypertension is characteristically associated with vascular dysfunction, cardiovascular remodeling, renal dysfunction, and stimulation of the sympathetic nervous system.