Rhyll E. Smythe on Muck Rack

Rhyll E. Smythe

As seen in: Nature
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Articles

Ischaemic endothelial necroptosis induces haemolysis and COVID-19 angiopathy - Nature

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By Rhyll E. Smythe, Eduardo A. Albornoz, Jonathan E Noonan, Trent M Woodruff, André Samson, Simone M. Schoenwaelder, Ethan Italiano, Rocko Jarvis-Child, Alexandra F. Sharland
| Nature Verified
Abstract Microangiopathy is a major complication of SARS-CoV-2 infection and contributes to the acute and chronic complications of the disease1. Endotheliopathy and dysregulated blood coagulation are prominent in COVID-19 and are considered to be major causes of microvascular obstruction1,2. Here we demonstrate extensive endothelial cell (EC) death in the microvasculature of COVID-19 organs.
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Development of supramolecular anticoagulants with on-demand reversibility - Nature Biotechnology

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By Millicent Dockerill, Jorge Ripoll-Rozada, Richard Payne, Rhyll E. Smythe, Shaun P. Jackson
| Nature Verified
Abstract Drugs are administered at a dosing schedule set by their therapeutic index, and termination of action is achieved by clearance and metabolism of the drug. In some cases, such as anticoagulant drugs or immunotherapeutics, it is important to be able to quickly reverse the drug’s action.
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