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Ricarda Bardenhewer on Muck Rack

Ricarda Bardenhewer

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Topographically organized dorsal raphe activity modulates forebrain sensory-motor representations and contributes to defensive behaviors

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By Aytac Kadir Mutlu, Bram Serneels, Christoph Wiest, Anh-Tuan Trinh, Fabrizio Palumbo, Anna Maria Ostenrath, Emre Yaksi, Ricarda Bardenhewer, Oda Bjørnevik Frisvold
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Abstract The dorsal raphe nucleus (DRN) shapes behaviors including mood and motivation. The DRN contains molecularly distinct and topographically organized neurons that target specific forebrain regions. To understand how DRN neurons process sensory information, we investigated the spatiotemporal activity patterns of DRN neurons, DRN axons, and their forebrain targets in zebrafish. We found a remarkable topographic organization of ongoing activity and sensory-motor responses within the DRN.
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