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Richard Bardin

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Clinicopathological Features, Treatment Response, and Outcome of Rosai-Dorfman Disease in Two Children

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By George Evele, Kouya Francine, Richard Bardin
| Wiley Online Library Verified
1 Introduction Rosai-Dorfman disease (RDD) is a rare and distinct form of non-Langerhans cell histiocytosis [1]. RDD is characterized by the abnormal accumulation or infiltration of activated tissue-resident macrophages (histiocytes), resulting in a range of systemic manifestations [1, 2]. In 1965, Destombes was the first to report histopathological findings of RDD in four African children with lymphadenopathy, a condition he termed “Adenitis with Lipid Excess.” [2].
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