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Richard McShinsky

As seen in: Nature, MDEdge
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Articles by Richard McShinsky

Computer-guided dosing of multi-specific T-cell engagers

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By Richard McShinsky, Katarzyna Modzelewska, Lauren Naatz, Alex Stark, Douglas Sborov, Shawn Owen, Isaac Kendell, Jeffry Troll, M. Tommy Gambles
| Nature Verified
Abstract Patient-specific tumor heterogeneity limits the efficacy of conventional T-cell immunotherapies. We report MATCH, a modular split-antibody T-cell engager platform, and COMPASS, a computational framework that predicts individualized multi-specific therapy compositions. COMPASS integrates T-cell counts, tumor burden, and antigen expression (CD19, CD20, CD38) to identify dose combinations that maximize tumor cell killing while preserving T-cell viability.
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Hematology and Oncology Staffing Levels for Fiscal Years 19–24 | MDedge

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By Christina Yong, Apar Kishor Ganti, Katherine Faricy-Anderson, Richard McShinsky
| MDEdge Verified
Background Department of Veterans Affairs (VA) faces a landscape of increasingly complex practice, especially in Hematology/Oncology (H/O), and a nationwide shortage of healthcare providers, while serving more Veterans than ever before.
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