Introduction The clinical strategy of aggressively reducing low-density lipoprotein cholesterol (LDL-C) to prevent adverse cardiovascular (CV) events in high-risk patients has consistently and unambiguously shown that “lower is better.”1-5 Scores of high-quality clinical trials have led to the current consensus approach for treating hypercholesterolemia starting with statin therapy.1,6-9 Clinicians typically prescribe an effective statin, such as atorvastatin or rosuvastatin, titrated to the...