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Ridha Ben Salem

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Articles

Palladium‐Catalyzed C4,C5‐Diarylation of Isoxazole‐3‐carboxylate by Double C-H Bond Functionalization

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By Linhao Liu, Henri Doucet, Rabeb Ben Romdhane, Ridha Ben Salem
| Wiley Online Library Verified
Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.
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Palladium‐Catalyzed C4,C5‐Diarylation of Isoxazole‐3‐Carboxylate by Double C−H Bond Functionalization

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By Rabeb Ben Romdhane, Linhao Liu, Ridha Ben Salem, Henri Doucet
| Wiley Online Library Verified
Introduction Isoxazole units bearing aryl substituents at C3-, C4- and/or C5-positions are widely used in medicinal chemistry.1 For example, Parecoxib is an anti-inflammatory drug and 4,5-diaryl isoxazole Luminespib is an experimental drug candidate for the treatment of cancer (Figure 1). Therefore, the discovery of simple methods for the access to polyarylated isoxazoles is an important research topic in medicinal chemistry.
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