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Ridita Khan

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Articles

Multi-omics analysis links kynurenic acid to lithium response in bipolar disorder

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By Mete Ercis, Patrik Fridh, Brandon J Coombes, Alfredo Cuellar-Barboza, Miguel Prieto, Susan L. McElroy, Balwinder Singh, Aysegul Ozerdem, Joanna M. Biernacka, Sophie Erhardt, Mark Frye, Lindsay M. Melhuish Beaupre, Ridita Khan, Jacob Ahlberg Weidenfors
| Nature Verified
Abstract The kynurenine pathway (KP) is implicated in bipolar disorder through its effects on glutamate signaling and neuroinflammation, but its role in clinical heterogeneity and treatment response is unclear. We used a multi-omic approach to test whether KP metabolites and their corresponding genetic risk scores are associated with clinical phenotypes, particularly response to lithium.
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