Rie Yamamoto

Abstract This study investigated the association between temporomandibular joint osteoarthritis and specific single-nucleotide polymorphisms. We also explored the potential functional impacts of these polymorphisms using in silico methods. 354 patients with temporomandibular disorders were classified into osteoarthritis and without osteoarthritis according to the presence of degenerative bone changes in the magnetic resonance imaging including osteophytes, erosion, subchondral cysts, and atrophy.

1 Introduction Diverse repetitive amino acid sequences exist in nature, each possessing distinctive functions.[1-5] Recombinant protein polymers inspired by these characteristics have attracted attention as sustainable and biocompatible materials synthesized using environment-friendly processes.[6, 7] The applications of these polymers are expanding to high-toughness fibers,[8, 9] ultra-high elastic materials,[10, 11] cell culture substrates,[12, 13] bioseparation,[14, 15] drug delivery,[16,...

Abstract Recombinant protein polymers with repeat sequences of specific amino acids can be regarded as sustainable functional materials that can be designed using genetic engineering. However, synthesizing genes encoding these proteins is significantly time-consuming and labor-intensive owing to the difficulty of using common gene synthesis tools, such as restriction enzymes and PCR primers.