Citation: Li X, Quan L, Zhou R, Liu X, Sarid R, Kuang E (2025) ORF45-induced Filamin A phosphorylation promotes cell motility and cell-contact dependent viral infection of Kaposi’s sarcoma-associated herpesvirus. PLoS Pathog 21(11): e1013737. https://doi.org/10.1371/journal.ppat.1013737 Editor: Shou-Jiang Gao, UPMC Hillman Cancer Center, UNITED STATES OF AMERICA Received: July 9, 2025; Accepted: November 17, 2025; Published: November 24, 2025 Copyright: © 2025 Li et al.