Rikke Guldhammer Nejrup on Muck Rack

Rikke Guldhammer Nejrup

As seen in: MDPI
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Articles

Defensin Interactions in Relation to Monoclonal and Disease-Related Proteinase 3 Antibodies Binding at the Catalytic Site

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By Nicole Hartwig Trier, Anna Chailyan, Morten Zoega, Rikke Guldhammer Nejrup
| MDPI
Abstract : Proteinase 3 (PR3) is a neutrophil granulocyte enzyme and an autoantigen found in several forms of vasculitis. Due to the diagnostic and clinical importance of antibodies (Abs) to PR3, it is important to characterize the protein and the nature of its epitopes. Here, we have characterized PR3 monoclonal antibodies (MAbs) and disease-associated Abs and their dependency on the PR3 structure and modifications, especially interactions with α-defensins.
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